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Clinical validation of the novel fluorescent glomerular filtration rate tracer agent relmapirazin (MB-102)
Thursday, September 12th, 2024
Richard B. Dorshow, Martin P. Debreczeny, Stuart L. Goldstein and Jeng-Jong Shieh,”Clinical validation of the novel fluorescent glomerular filtration rate tracer agent relmapirazin (MB-102)”, Kidney
Transdermal Detection of MB-102 and Correlation to Meropenem Pharmacokinetics During Continuous Renal Replacement Therapy: In Vivo Results
Monday, May 8th, 2023
Richard B. Dorshow, James R. Johnson, Jeng-Jong Shieh, I. Rochelle Riley, Thomas E. Rogers, Christopher J. Pino, Kimberly A. Johnston, Peter Tang, Thomas D. Nolin,
Adsorption and Clearance of the Novel Fluorescent Tracer Agent MB-102 During Continuous Renal Replacement Therapy: In Vitro Results
Monday, May 8th, 2023
Soo M. Jang Jeng-Jong Shieh, Ivan R. Riley, Richard B. Dorshow, and Bruce A. Mueller, “Adsorption and Clearance of the Novel Fluorescent Tracer Agent MB-102
Evaluation of Developmental and Reproductive Toxicity in Rabbits for MB-102, a Fluorescent Tracer Agent Designed for Real-Time Measurement of Glomerular Filtration Rate
Wednesday, July 13th, 2022
Joseph E. Bugaj, Richard B. Dorshow, “Evaluation of Developmental and Reproductive Toxicity in Rabbits for MB-102, a Fluorescent Tracer Agent Designed for Real-Time Measurement of
Absence of developmental or reproductive toxicity in rats for MB-102, a fluorescent tracer agent for point-of-care measurement of glomerular filtration rate
Friday, April 15th, 2022
Joseph E. Bugaj , Richard B. Dorshow, “Absence of developmental or reproductive toxicity in rats for MB-102, a fluorescent tracer agent for point-of-care measurement of
Characterization of MB-102, a New Fluorescent Tracer Agent for Point-of-Care Renal Function Monitoring
Sunday, January 12th, 2020
Jeng-Jong Shieh, I. Rochelle Riley, Thomas E. Rogers, Lung-Fa Kao, Richard B. Dorshow, “Characterization of MB-102, a New Fluorescent Tracer Agent for Point-of-Care Renal Function
Next tier in vitro and in vivo nonclinical studies further elucidating the safety and toxicity profile of MB-102, a novel fluorescent tracer agent for measurement of glomerular filtration rate
Friday, January 10th, 2020
Richard B. Dorshow, Joseph E. Bugaj, “Next tier in vitro and in vivo nonclinical studies further elucidating the safety and toxicity profile of MB-102, a
Clinical analysis and quantitation of MB-102, a novel fluorescence tracer agent, in human plasma
Tuesday, January 7th, 2020
Jeng-Jong Shieh, Rochelle Riley, Richard B. Dorshow, “Clinical analysis and quantitation of MB-102, a novel fluorescence tracer agent, in human plasma,” The Royal Society of
Latest Results from the On-going Clinical Studies Utilizing the Novel Fluorescent Tracer Agent MB-102 for Transdermal Glomerular Filtration Rate Measurement
Monday, January 6th, 2020
Richard B. Dorshow, Martin P. Debreczeny, James R. Johnson, Jeng-­Jong Shieh, Thomas E. Rogers, Kevin J. Martin, and Daniel W. Coyne, MediBeacon Inc., Division of
MB-102 Clearance During Ex Vivo Continuous Renal Replacement Therapy
Sunday, January 5th, 2020
Soo Min Jang, Jeng-Jong, Richard B. Dorshow, Bruce A. Mueller, Department of Clinical Pharmacy, College of Pharmacy, Univeristy of Michigan, presented at the 23rd International
Transdermal optical renal function monitoring in humans: development, verification, and validation of a prototype device
Saturday, January 4th, 2020
Martin P. Debreczeny, Richard B. Dorshow, “Transdermal optical renal function monitoring in humans: development, verification, and validation of a prototype device,” Journal of Biomedical Optics,
Clinical Study Results of a Real-Time Point-of-Care Glomerular Filtration Rate Measurement
Friday, January 3rd, 2020
Richard B. Dorshow, Martin P. Debreczeny, James R. Johnson, Jeng-Jong Shieh, Thomas E. Rogers, Kevin J. Martin, Daniel W. Coyne, presented at the American Society
Development and clinical trial results of a prototype device for trans-cutaneous monitoring of kidney function
Thursday, January 2nd, 2020
M.P. Debreczeny and R.B. Dorshow, “Development and clinical trial results of a prototype device for trans-cutaneous monitoring of kidney function,” Reporters, Markers, Dyes, Nanoparticles, and
Modeling of transdermal fluorescence measurements from first-in-human clinical trials for renal function determination using fluorescent tracer agent MB-102
Monday, December 30th, 2019
K.M. Shultz, M.P. Debreczeny, R.B. Dorshow, J.E. Keating, and K.L. Bechtel, “Modeling of transdermal fluorescence measurements from first-in-human clinical trials for renal function determination using
Initial Clinical Trial Results of a Real-Time Point-of-Care Glomerular Filtration Rate Measurement Utilizing a Novel Fluorescent Tracer Agent
Saturday, December 28th, 2019
Richard B. Dorshow, Martin P. Debreczeny, Jeffrey C. Fink, and Thomas C. Dowling, presented at the American Society of Nephrology Kidney Week Meeting, San Diego,
Pre-clinical toxicity evaluation of MB-102, a novel fluorescent tracer agent for real-time measurement of glomerular filtration rate
Friday, December 27th, 2019
Joseph E. Bugaj, Richard B. Dorshow, “Pre-clinical toxicity evaluation of MB-102, a novel fluorescent tracer agent for real-time measurement of glomerular filtration rate,” Regulatory Toxicology
Results of the First-in-Human Clinical Trial for MB-102, a Novel Fluorescent Tracer Agent for Real-Time Measurement of Glomerular Filtration Rate
Thursday, December 26th, 2019
R.B. Dorshow, M.P. Debreczeny, and T.C. Dowling, “Results of the first-in-human clinical trial for MB-102, a novel fluorescent tracer agent for real-time measurement of glomerular
Initial Formal Toxicity Evaluation of APC-2, a Novel Fluorescent Tracer Agent for Real-Time Measurement of Glomerular Filtration Rate in Preparation for a first-in-man clinical trial
Wednesday, December 25th, 2019
J.E. Bugaj and R.B. Dorshow, “ Initial Formal Toxicity Evaluation of APC-2, a Novel Fluorescent Tracer Agent for Real-Time Measurement of Glomerular Filtration Rate in
Kidney Function Monitoring: Pathway to the Future
Tuesday, December 24th, 2019
Richard B. Dorshow, PhD. “Kidney Function Monitoring: Pathway to the Future” in Renal Business Today, November 2013.
Real-time point-of-care measurement of impaired renal function in a rat acute injury model employing exogenous fluorescent tracer agents
Sunday, December 22nd, 2019
Richard B. Dorshow, Richard M. Fitch, Karen P. Galen, Jolette K. Wojdyla, Amruta R. Poreddy, John N. Freskos, Raghavan Rajagopalan, Jeng-Jong Shieh, and Sevag G.
Real-time point-of-care measurement of impaired renal function in a rat acute injury model employing exogenous fluorescent tracer agents
Sunday, December 22nd, 2019
Richard B. Dorshow, Richard M. Fitch, Karen P. Galen, Jolette K. Wojdyla, Amruta R. Poreddy, John N. Freskos, Raghavan Rajagopalan, Jeng-Jong Shieh, and Sevag G.
Exogenous fluorescent agents for the determination of glomerular filtration rate
Saturday, December 21st, 2019
R. Rajagopalan and R.B. Dorshow, “Exogenous fluorescent agents for the determination of glomerular filtration rate,” in Chronic Kidney Disease, edited by M. Gooz (Intech, Rijeka,
Exogenous fluorescent tracer agents based on pegylated pyrazine dyes for real-time point-of-care measurement of glomerular filtration rate
Friday, December 20th, 2019
A.R. Poreddy, W.L. Neumann, J.N. Freskos, R. Rajagopalan, B. Asmelash, K.R. Gaston, R.M. Fitch, K.P. Galen, J.J. Shieh, and R.B. Dorshow, “Exogenous fluorescent tracer agents
Development of fluorescent tracers for the real-time monitoring of renal function
Thursday, December 19th, 2019
A.R. Poreddy, B. Asmelash, M.P. Debreczeny, R.M. Fitch, J.N. Freskos, K.P. Galen, K.R. Gaston, J.G. Kostelc, R. Kumar, T.A. Marzan, W.L. Neumann, R. Rajagopalan, T.M.
Hydrophilic pyrazine dyes as exogenous fluorescent tracer agents for real-time point-of-care measurement of glomerular filtration rate
Tuesday, December 17th, 2019
R. Rajagopalan, W.L. Neumann, A.R. Poreddy, R.M. Fitch, J.N. Freskos, B. Asmelash, K.R. Gaston, K.P. Galen, J.J. Shieh, and R.B. Dorshow, “Hydrophilic pyrazine dyes as
A highly efficient method for the N-alkylation of amino pyrazines: synthesis of hydrophilic red fluorescent dyes
Monday, December 16th, 2019
A.R. Poreddy, B. Asmelash, W.L. Neumann, and R.B. Dorshow, “A highly efficient method for the N-alkylation of amino pyrazines: synthesis of hydrophilic red fluorescent dyes,”
N-Alkylated amino pyrazines for use as hydrophilic optical agents
Sunday, December 15th, 2019
A.R. Poreddy, B. Asmelash, K.P. Galen, R.M. Fitch, J.J. Shieh, J.M. Wilcox, T.M. Schoenstein, J.K. Wojdyla, K.R. Gaston, J.N. Freskos, W.L. Neumann, R. Rajagopalan, H.Y.Ahn,
Fluorescence-enhanced europium complexes for the assessment of renal function
Friday, December 13th, 2019
L.K. Chinen, K.P. Galen, K.T. Kuan, M.E. Dyszlewski, H. Ozaki, H. Sawai, R.S. Pandurangi, F.G. Jacobs, R.B. Dorshow, and R. Rajagopalan, “Fluorescence-enhanced europium complexes for
Fluorescence-enhanced Europium-Diethylenetriaminepentaacetic (DTPA)-Monoamide complexes for the Assessment of Renal Function
Friday, December 13th, 2019
L.K. Chinen, K.P. Galen, K.T. Kuan, M.E. Dyszlewski, H. Ozaki, H. Sawai, R.S. Pandurangi, F.G. Jacobs, R.B. Dorshow, and R. Rajagopalan, “Fluorescence-enhanced Europium-Diethylenetriaminepentaacetic (DTPA)-Monoamide complexes
New optical probes for continuous monitoring of renal function
Thursday, December 12th, 2019
R.B. Dorshow, B. Asmelash, L.K. Chinen, M.P. Debreczeny, R.M. Fitch, J.N. Freskos, K.P. Galen, K.R. Gaston, T.A. Marzan, A.R. Poreddy, R. Rajagopalan, J.-J. Shieh, and

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