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GASTROENTEROLOGY
Advances in fluorescent technology brought to light.
Read the Publications >>
MediBeacon Gastroenterology Program
Focus is on GI permeability to transform management of autoimmune and inflammatory diseases

CLINICAL PROGRAM
In healthy people, the wall of the intestine forms a barrier between the contents of the gut and the rest of the body, with only the nutrients produced by digestion passing through. If the intestine becomes more permeable, other molecules or bacteria from the gut may also get through, producing inflammation and other medical problems. This means that methods for effectively measuring intestinal permeability are of great interest for the management of conditions such as inflammatory bowel disease.

Clinical studies have been conducted to understand how fluorescent tracer agent-based systems might prove of clinical utility in the permeability of the gastrointestinal tract. Permeability in patients with Crohn's Disease and other conditions which might be related to abnormal gastrointestinal barrier function is of interest to researchers and clinicians.*

GI PUBLICATIONS
MediBeacon gut permeability research is being completed in collaboration with researchers at the Mayo Clinic, at Washington University in St. Louis and in partnership with investigators at the Imperial College of London. Results from initial studies are the subject of peer-reviewed publications.

Read the Publications >>
Increased intestinal permeability is implicated in autoimmune diseases. Examples include Inflammatory Bowel Disease (IBD), celiac disease, and type 1 diabetes, all of which are characterized by abnormal intestinal permeability.
- Journal of American Society for Nutrition, Uluwishewa D. et al., Regulation of tight junction permeability by intestinal bacteria and dietary components, 2011
“To our knowledge, this prospective study is the first to show that abnormal intestinal permeability is a significant predisease risk factor of CD onset that precedes disease development by more than 3 years.”
- Increased Intestinal Permeability Is Associated With Later Development of Crohn’s Disease, Gastroenterology 2020;159:2092–2100
“In spite of the challenges in developing this new arena of disease prediction and prevention in IBD, it is clear that major advances in understanding the predisease stages, the nature of risk, and the nature of possible triggers of disease are paving the way for the development of a new era where disease intervention and disease modification will be a real possibility.”
- Prediction and Prevention of Inflammatory Bowel Disease, Clinical Gastroenterology and Hepatology 2025;23:396–405
In the US IBD care costs
as much as
$32B
ANNUALLY
– The American Journal of Managed Care, Foram Mehta., Economic implications of inflammatory bowel disease and its management, March 2016
Growing Research Interest
Peer-reviewed publications on Intestinal Permeability have increased to >2,500 annually in 2024.
– PubMed entries on “intestinal permeability,” 1970-2018
FUNDING FROM THE BILL & MELINDA GATES FOUNDATION
Washington University School of Medicine, in collaboration with MediBeacon has received Grand Challenges Explorations and Grand Challenges Explorations Phase II grants totaling over $1 million. Grand Challenges Explorations is an initiative funded by the Bill & Melinda Gates Foundation.

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